Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.39 |
| ▸ | WDR91 | A4D1P6 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726458 | 0.85 | PRKAG1 (0.40) | ARPRKAG1PRKAA1PRKAB1WDR91 | |
| SCHEMBL20726434 | 0.83 | ERBB2 (0.39) | ARPRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL20726349 | 0.82 | ERBB2 (0.41) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL26114838 | 0.79 | PRKAG1 (0.36) | ARPRKAG1PRKAA1PRKAB1WDR91 | |
| SCHEMBL30629830 | 0.79 | PRKAG1 (0.36) | ARPRKAG1PRKAA1PRKAB1WDR91 | |
| SCHEMBL16824290 | 0.79 | PRKAG1 (0.36) | ARPRKAG1PRKAA1PRKAB1WDR91 | |
| SCHEMBL16824289 | 0.79 | PRKAG1 (0.36) | ARPRKAG1PRKAA1PRKAB1WDR91 | |
| SCHEMBL20726519 | 0.78 | CHRM5 (0.34) | SYK | |
| SCHEMBL20726517 | 0.78 | PRKAG1 (0.39) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL16824543 | 0.77 | PRKAG1 (0.36) | ARPRKAG1PRKAA1PRKAB1WDR91 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |