Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | OGA | O60502 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.35 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2376107 | 0.78 | SMG1 (0.56) | HRH4OGAJAK2JAK1JAK3 | |
| SCHEMBL2375403 | 0.74 | PLK4 (0.55) | JAK2JAK1JAK3FLT3NR2C2 | |
| SCHEMBL2376050 | 0.73 | CYP3A4 (0.46) | HRH4CDK4CDK6JAK2JAK1 | |
| SCHEMBL31681826 | 0.73 | CYP3A4 (0.46) | HRH4CDK4CDK6JAK2JAK1 | |
| SCHEMBL2375410 | 0.72 | ZAP70 (0.61) | — | |
| SCHEMBL2374148 | 0.71 | JAK2 (0.56) | JAK2JAK1JAK3SMG1PARP1 | |
| SCHEMBL2375211 | 0.71 | SMG1 (0.51) | OGANR2C2TAB1SMG1CDK1 | |
| SCHEMBL31681845 | 0.71 | SMG1 (0.51) | OGANR2C2TAB1SMG1CDK1 | |
| SCHEMBL12231947 | 0.70 | ZAP70 (0.49) | JAK2JAK1JAK3SMG1TTK | |
| SCHEMBL30839088 | 0.70 | JAK2 (0.64) | JAK2JAK1JAK3FLT3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3623374-A1 | STEM CELL CULTURES | The Scripps Research Institute (US) | 2020-03-18 | — | — | EP | disclosed |
| EP-3441394-A1 | STEM CELL CULTURES | The Scripps Research Institute (US) | 2019-02-13 | — | — | EP | disclosed |