Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904299 | 0.76 | KDM4E (0.61) | KDM4EHPGDACHELMNAHSD17B10 | |
| SCHEMBL7519734 | 0.76 | KDM4E (0.61) | KDM4EHPGDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27393494 | 0.73 | KDM4E (0.57) | KDM4EHPGDACHECYP1A2HSD17B10 | |
| SCHEMBL1154871 | 0.71 | KDM4E (0.56) | KDM4EHPGDLMNAHSD17B10ALDH1A1 | |
| SCHEMBL12956699 | 0.71 | KDM4E (0.55) | KDM4EHPGDACHECYP1A2LMNA | |
| SCHEMBL25057053 | 0.70 | KDM4E (0.54) | KDM4EHPGDACHECYP1A2HSD17B10 | |
| SCHEMBL2074476 | 0.69 | HPGD (0.60) | KDM4EHPGDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6798736 | 0.68 | L3MBTL1 (0.63) | KDM4EHPGDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL933760 | 0.68 | CYP1A2 (0.57) | KDM4EHPGDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5783945 | 0.68 | KDM4E (0.51) | KDM4EHPGDACHELMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |