Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | VNN1 | O95497 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904299 | 0.83 | KDM4E (0.61) | HPGDTSHRLMNAHTTMAPK10 | |
| SCHEMBL10559807 | 0.81 | LTA4H (0.60) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL2074950 | 0.74 | KDM4E (0.51) | HPGDTSHRLMNASMN1; SMN2KDM4E | |
| SCHEMBL1154965 | 0.73 | HTR1A (0.49) | HPGDTSHRLMNAHTTMAPK10 | |
| SCHEMBL8773039 | 0.71 | ALDH1A1 (0.74) | LMNAKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL27393494 | 0.71 | KDM4E (0.57) | HPGDSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL27218624 | 0.70 | MEN1 (0.54) | ALDH1A1MEN1MAPTKMT2APABPC1 | |
| SCHEMBL28255594 | 0.70 | PDE4A (0.57) | HPGDTSHRLMNAHTTMAPK10 | |
| SCHEMBL10558180 | 0.70 | CYP3A4 (0.68) | HPGDTSHRKDM4EALDH1A1MEN1 | |
| SCHEMBL22792288 | 0.69 | ALDH1A1 (0.51) | HPGDTSHRLMNAHTTMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |