Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | USP28 | Q96RU2 | 8/20 | 0.41 |
| ▸ | USP25 | Q9UHP3 | 8/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20731005 | 0.84 | ALDH1A1 (0.62) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 | |
| SCHEMBL19267554 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 | |
| SCHEMBL20732193 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 | |
| SCHEMBL11486062 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 | |
| SCHEMBL21704293 | 0.77 | IKBKB (0.56) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 | |
| SCHEMBL20731630 | 0.76 | KDM4E (0.38) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 | |
| SCHEMBL20731980 | 0.76 | USP28 (0.39) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 | |
| SCHEMBL12562427 | 0.75 | LIMK1 (0.77) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 | |
| SCHEMBL19212039 | 0.75 | LIMK1 (0.77) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 | |
| SCHEMBL29707312 | 0.75 | LIMK1 (0.77) | ALDH1A1KDM4ESMN1; SMN2IKBKBLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |