Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | USP28 | Q96RU2 | 12/20 | 0.40 |
| ▸ | USP25 | Q9UHP3 | 9/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957291 | 0.82 | IKBKB (0.49) | IKBKBLIMK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL20731005 | 0.77 | ALDH1A1 (0.62) | IKBKBLIMK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL20731982 | 0.77 | ALDH1A1 (0.62) | IKBKBLIMK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL12562427 | 0.72 | LIMK1 (0.77) | IKBKBLIMK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL16071461 | 0.72 | IKBKB (1.00) | IKBKBLIMK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL19212039 | 0.72 | LIMK1 (0.77) | IKBKBLIMK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL29707312 | 0.72 | LIMK1 (0.77) | IKBKBLIMK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL19465955 | 0.72 | MEN1 (0.63) | ALDH1A1KDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL19267554 | 0.71 | ALDH1A1 (0.53) | IKBKBLIMK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL20732193 | 0.71 | ALDH1A1 (0.55) | IKBKBLIMK1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913753-B2 | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | VALO EARLY DISCOVERY, INC. (US) | 2021-02-09 | — | — | US | disclosed |
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913753-B2 | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | USP28, USP25, USP24 | IKBKB 410/4885LIMK1 4691/4885ALDH1A1 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.