Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | USP28 | Q96RU2 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 3/20 | 0.46 |
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | PRKACB | P22694 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | USP25 | Q9UHP3 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC14A1 | Q13336 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211014 | 0.88 | USP28 (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL20731112 | 0.88 | IKBKB (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL21457814 | 0.84 | KDM4E (0.63) | KDM4EALDH1A1HPGDSMN1; SMN2USP28 | |
| SCHEMBL21704060 | 0.82 | USP28 (0.44) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL22645007 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL20731139 | 0.76 | IKBKB (0.37) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL20731810 | 0.76 | LIMK1 (0.38) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL19769230 | 0.75 | KDM4E (1.00) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL12562427 | 0.73 | LIMK1 (0.77) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL24248117 | 0.72 | IKBKB (0.49) | KDM4EALDH1A1HPGDSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |