Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 11/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 12/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | PRKACB | P22694 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211014 | 0.82 | USP28 (0.47) | USP28USP25IKBKBLIMK1KDM4E | |
| SCHEMBL20732017 | 0.82 | KDM4E (0.60) | USP28USP25IKBKBLIMK1KDM4E | |
| SCHEMBL20731112 | 0.82 | IKBKB (0.60) | USP28IKBKBLIMK1KDM4ECHUK | |
| SCHEMBL21457814 | 0.79 | KDM4E (0.63) | USP28KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21704266 | 0.76 | LIMK1 (0.69) | USP28USP25IKBKBLIMK1KDM4E | |
| SCHEMBL20731139 | 0.72 | IKBKB (0.37) | USP28USP25IKBKBLIMK1KDM4E | |
| SCHEMBL20731810 | 0.72 | LIMK1 (0.38) | USP28USP25IKBKBLIMK1KDM4E | |
| SCHEMBL24248117 | 0.68 | IKBKB (0.49) | IKBKBLIMK1KDM4ECHUKPRKACA | |
| SCHEMBL22645007 | 0.66 | KDM4E (0.47) | USP28USP25IKBKBLIMK1KDM4E | |
| SCHEMBL24248139 | 0.66 | ALDH1A1 (0.39) | USP28USP25IKBKBLIMK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |