Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 18/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20733330 | 0.82 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL20733327 | 0.78 | CRHR1 (0.75) | CRHR1 | |
| SCHEMBL22106778 | 0.74 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL21886231 | 0.74 | CRHR1 (0.62) | CRHR1KDR | |
| SCHEMBL21886139 | 0.72 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL7218557 | 0.70 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL21886232 | 0.70 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL21886154 | 0.70 | CRHR1 (0.66) | CRHR1 | |
| SCHEMBL8202018 | 0.68 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL21886412 | 0.68 | CRHR1 (0.60) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370793-B2 | Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau | NANTNEURO, LLC (US) | 2022-06-28 | — | — | US | disclosed |
| US-20220024935-A1 | Triazolopyridines And Triazolopyrimidines That Lower Stress-Induced P-Tau | NANTNEURO LLC (US) | 2022-01-27 | — | — | US | disclosed |
| US-20190048012-A1 | Triazolopyridines And Triazolopyrimidines That Lower Stress-Induced P-Tau | NANTNEURO, LLC | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11370793-B2 | Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau | MAPT, CRH, CRHBP | CRHR1 22/4885EGFR 4447/4885PDGFRB 4541/4885 |
| US-20190048012-A1 | Triazolopyridines And Triazolopyrimidines That Lower Stress-Induced P-Tau | MAPT, CRH, CRHBP | CRHR1 22/4885EGFR 4447/4885PDGFRB 4541/4885 |
| US-20220024935-A1 | Triazolopyridines And Triazolopyrimidines That Lower Stress-Induced P-Tau | MAPT, CRH, CRHBP | CRHR1 22/4885EGFR 4447/4885PDGFRB 4541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.