Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16576322 | 1.00 | ALDH1A1 (0.52) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL17976785 | 1.00 | ALDH1A1 (0.52) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL20557343 | 1.00 | ALDH1A1 (0.52) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL15414469 | 0.85 | ALDH1A1 (0.49) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL14615421 | 0.85 | ALDH1A1 (0.49) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL13649180 | 0.84 | ALDH1A1 (0.51) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL13708365 | 0.84 | ALDH1A1 (0.53) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL27195217 | 0.83 | ALDH1A1 (0.44) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL27195193 | 0.83 | ALDH1A1 (0.44) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL28718478 | 0.82 | ALDH1A1 (0.47) | ALDH1A1CHRNB2CHRNA5CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368204-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2024-11-07 | — | — | US | disclosed |
| EP-4353732-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2024-04-17 | — | — | EP | disclosed |
| CN-117642411-A | Small molecule CD73 antagonists and uses thereof | 西藏海思科制药有限公司 | 2024-03-01 | — | — | CN | disclosed |
| WO-2022237747-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | 四川海思科制药有限公司 | 2022-11-17 | — | — | WO | disclosed |
| WO-2022237747-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | 四川海思科制药有限公司 | 2022-11-17 | — | — | WO | disclosed |
| US-20220160713-A1 | SELECTIVE INHIBITOR OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | WILMINGTON PHARMATECH COMPANY, LLC | 2022-05-26 | — | — | US | disclosed |
| US-11208416-B2 | Selective inhibitors of protein arginine methytransterase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED (US) | 2021-12-28 | — | — | US | disclosed |
| US-11078205-B2 | Selective inhibitors of protein arginine methlytransferase 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2021-08-03 | — | — | US | disclosed |
| US-20200361946-A1 | Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2020-11-19 | — | — | US | disclosed |
| US-20200148692-A1 | Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2020-05-14 | — | — | US | disclosed |
| WO-2019032859-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078205-B2 | Selective inhibitors of protein arginine methlytransferase 5 (PRMT5) | PRMT5, PRMT1, PRMT3 | ALDH1A1 3226/4885CHRNB2 4165/4885CHRNA5 2029/4885 |
| US-20240368204-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | ENTPD5, ENTPD1, ENTPD2 | ALDH1A1 507/4885CHRNB2 777/4885CHRNA5 236/4885 |
| US-20200148692-A1 | Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | ALDH1A1 3770/4885CHRNB2 2675/4885CHRNA5 550/4885 |
| US-11208416-B2 | Selective inhibitors of protein arginine methytransterase 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | ALDH1A1 3770/4885CHRNB2 2675/4885CHRNA5 550/4885 |
| US-20220160713-A1 | SELECTIVE INHIBITOR OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | ALDH1A1 4156/4885CHRNB2 4559/4885CHRNA5 2175/4885 |
| US-20200361946-A1 | Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | ALDH1A1 3770/4885CHRNB2 2675/4885CHRNA5 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.