Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557573 | 0.88 | KDM4E (0.67) | GAAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL13622686 | 0.80 | KDM4E (0.62) | GAAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL2072485 | 0.79 | KDM4E (1.00) | GAAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL30332131 | 0.79 | GAA (0.67) | GAAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL14804200 | 0.77 | CYP3A4 (0.53) | GAAKDM4EALDH1A1HPGDRECQL | |
| SCHEMBL8569982 | 0.77 | ALDH1A1 (0.73) | GAAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL29952998 | 0.76 | NOTUM (0.59) | GAAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL2560204 | 0.76 | NOTUM (0.59) | GAAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL29955236 | 0.76 | NOTUM (0.59) | GAAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL25154979 | 0.76 | GAA (0.52) | GAAKDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |