Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1154557 | 0.98 | KDM4E (0.71) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL16793536 | 0.98 | KDM4E (0.71) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL29599792 | 0.85 | KDM4E (1.00) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL2075341 | 0.85 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL3076269 | 0.85 | KDM4E (0.68) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL10934231 | 0.85 | KDM4E (0.68) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL823501 | 0.85 | KDM4E (1.00) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL22964425 | 0.83 | KDM4E (0.66) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL2072485 | 0.82 | KDM4E (1.00) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL1878340 | 0.81 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| CN-1035001-C | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1997-05-28 | — | — | CN | disclosed |
| CN-1088906-A | The phenyl phenol leukotriene antagonists that replaces | LILLY CO ELI (US) | 1994-07-06 | — | — | CN | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |