SCHEMBL20734347

SCHEMBL20734347

c1ccc(B2N(c3ccccc3)B(c3ccccc3)N(c3cccc(-c4nccc5c4sc4nc6ccccc6n45)c3)B(c3ccccc3)N2c2ccccc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.33
KMT2A Q03164 5/20 0.33
POLB P06746 4/20 0.33
MAPT P10636 4/20 0.33
HSD17B10 Q99714 2/20 0.33
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
RECQL P46063 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
APAF1 O14727 1/20 0.33
USP2 O75604 1/20 0.33
APEX1 P27695 1/20 0.33
DUSP3 P51452 1/20 0.33
MCL1 Q07820 1/20 0.33
NPC1 O15118 3/20 0.32
RAB9A P51151 3/20 0.32
SMN1; SMN2 Q16637 3/20 0.32
TP53 P04637 2/20 0.32
HIF1A Q16665 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20734348 0.86 KDM4E (0.36) MEN1KMT2APOLBMAPTHSD17B10
SCHEMBL20698250 0.75 HSD17B10 (0.39) MEN1KMT2APOLBMAPTHSD17B10
SCHEMBL20735546 0.74 HSD17B10 (0.36) MEN1KMT2APOLBMAPTHSD17B10
SCHEMBL22929990 0.72 SMN1; SMN2 (0.37) MEN1KMT2APOLBMAPTHSD17B10
SCHEMBL16441890 0.68 KDM4E (0.48) MEN1KMT2APOLBMAPTHSD17B10
SCHEMBL20734350 0.67 TDO2 (0.32)
SCHEMBL22100072 0.67 HSD17B10 (0.47) MEN1KMT2APOLBMAPTHSD17B10
SCHEMBL26198121 0.67 KDM4E (0.43) MEN1KMT2APOLBMAPTHSD17B10
SCHEMBL16441888 0.67 KDM4E (0.43) MEN1KMT2APOLBMAPTHSD17B10
SCHEMBL16441889 0.66 KDM4E (0.46) MEN1KMT2APOLBMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190051829-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION 2019-02-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190051829-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ORC3, BMP2, PPIP5K2 MEN1 2349/4885KMT2A 1905/4885POLB 2434/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.