Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20734899 | 1.00 | TSHR (0.45) | TSHRMEN1POLBKMT2AIDO1 | |
| SCHEMBL24333187 | 0.88 | MEN1 (0.42) | TSHRMEN1POLBKMT2AIDO1 | |
| SCHEMBL21929341 | 0.84 | MAOB (0.48) | IDO1MMP1MMP3MMP9ABCB1 | |
| SCHEMBL20734910 | 0.84 | MMP1 (0.48) | MEN1POLBKMT2AMMP1MMP3 | |
| SCHEMBL20734821 | 0.81 | ABCB1 (0.52) | MEN1KMT2AABCB1 | |
| SCHEMBL20734820 | 0.81 | ABCB1 (0.52) | MEN1KMT2AABCB1 | |
| SCHEMBL20734891 | 0.78 | PLA2G10 (0.39) | MEN1POLBKMT2A | |
| SCHEMBL20734897 | 0.78 | PLA2G10 (0.39) | MEN1POLBKMT2A | |
| SCHEMBL20734918 | 0.77 | AKR1B1 (0.42) | MEN1KMT2AMMP1MMP3MMP9 | |
| SCHEMBL20734917 | 0.77 | AKR1B1 (0.42) | MEN1KMT2AMMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332440-B2 | 4-oxo-alkylated tetramic acid compound, and preparation method thereof | BEIJING JOEKAI BIOTECH. LLC (CN) | 2022-05-17 | — | — | US | disclosed |
| US-11130733-B2 | 4-OXO-alkylated tetramic acid compound, preparation method and use thereof | BEIJING JOEKAI BIOTECH. LLC (CN) | 2021-09-28 | — | — | US | disclosed |
| US-20200361868-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD AND USE THEREOF | BEIJING JOEKAI BIOTECH. LLC (CN) | 2020-11-19 | — | — | US | disclosed |
| US-20200181081-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, AND PREPARATION METHOD THEREOF | BEIJING JOEKAI BIOTECH. LLC (CN) | 2020-06-11 | — | — | US | disclosed |
| EP-3647306-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND AND PREPARATION METHOD THEREFOR | Beijing Joekai Biotech. LLC (CN) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019029274-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND AND PREPARATION METHOD THEREFOR | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |
| WO-2019029273-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130733-B2 | 4-OXO-alkylated tetramic acid compound, preparation method and use thereof | HTT, PARK7, PSEN1 | TSHR 1337/4885MEN1 2261/4885POLB 1344/4885 |
| US-11332440-B2 | 4-oxo-alkylated tetramic acid compound, and preparation method thereof | PSEN1, PSEN2, APP | TSHR 2178/4885MEN1 1113/4885POLB 1828/4885 |
| US-20200181081-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, AND PREPARATION METHOD THEREOF | PSEN1, PSEN2, APP | TSHR 2178/4885MEN1 1113/4885POLB 1828/4885 |
| US-20200361868-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD AND USE THEREOF | HTT, PARK7, PSEN1 | TSHR 1337/4885MEN1 2261/4885POLB 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.