Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30547021 | 0.76 | HPGD (0.55) | LMNAHPGDHTR2AHTR2CHTR7 | |
| SCHEMBL410289 | 0.76 | HPGD (0.55) | LMNAHPGDHTR2AHTR2CHTR7 | |
| SCHEMBL1772458 | 0.76 | GSK3B (0.45) | LMNAHPGDMAPTL3MBTL1MAPK1 | |
| SCHEMBL24611517 | 0.74 | AHR (0.55) | HPGDMAPTNPSR1L3MBTL1MAPK1 | |
| SCHEMBL2428852 | 0.72 | HPGD (0.44) | LMNAHPGDMAPTNPSR1L3MBTL1 | |
| SCHEMBL24063528 | 0.70 | SIRT1 (0.55) | LMNAHPGDHTR2AHTR2CHTR7 | |
| SCHEMBL23612421 | 0.70 | ALDH1A1 (0.61) | LMNAHPGDHTR7HTR6MAPT | |
| SCHEMBL23101646 | 0.70 | MAP4K1 (0.46) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL4659161 | 0.70 | HTR6 (0.68) | LMNAHPGDHTR2AHTR7HTR6 | |
| SCHEMBL29366993 | 0.70 | CHUK (0.64) | LMNAHPGDMAPTNPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3444246-B1 | 2,4-DISUBSTITUTED PYRIMIDINE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF | SHANGHAI XUNHE PHARMACEUTICAL TECH CO LTD (CN) | 2019-11-06 | — | — | EP | disclosed |
| US-10464927-B2 | 2,4-disubstituted pyrimidines as CDK inhibitors | Shanghai Xunhe Pharmaceutical Technology Co. Ltd. (CN) | 2019-11-05 | — | — | US | disclosed |
| US-20190071427-A1 | 2,4-Disubstituted Pyrimidine Derivative as CDK Inhibitor and Use Thereof | CHENGDU JINRUI FOUNDATION BIOTECH CO., LTD. (CN) | 2019-03-07 | — | — | US | disclosed |
| EP-3444246-A1 | 2,4-DISUBSTITUTED PYRIMIDINE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF | Shanghai Xunhe Pharmaceutical Technology Co., Ltd. (CN) | 2019-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071427-A1 | 2,4-Disubstituted Pyrimidine Derivative as CDK Inhibitor and Use Thereof | CDK4, CDK2, CDK6 | LMNA 3205/4885HPGD 869/4885HTR2A 2971/4885 |
| US-10464927-B2 | 2,4-disubstituted pyrimidines as CDK inhibitors | CDK4, CDK2, CDK6 | LMNA 3329/4885HPGD 1053/4885HTR2A 2769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.