Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 8/20 | 0.69 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20740673 | 0.87 | DHFR (0.60) | DHFRTP53TSHRSLC2A1 | |
| SCHEMBL31155811 | 0.86 | DHFR (0.91) | DHFRPLA2G4BTP53TSHRHTT | |
| SCHEMBL20740675 | 0.85 | KMT2A (0.54) | DHFRPLA2G4BSLC2A1 | |
| SCHEMBL20740670 | 0.85 | DHFR (0.53) | DHFRSLC2A1 | |
| SCHEMBL20740678 | 0.80 | DHFR (0.52) | DHFRSLC2A1 | |
| SCHEMBL11171761 | 0.79 | DHFR (0.57) | DHFRSLC2A1 | |
| Hydrochloric Acid SCHEMBL11185095 | 0.78 | DHFR (0.56) | DHFRSLC2A1 | |
| SCHEMBL20740668 | 0.77 | DHFR (0.58) | DHFRSLC2A1HTT | |
| SCHEMBL118037 | 0.76 | PKM (0.77) | PLA2G4BTP53TSHRPKMRARB | |
| SCHEMBL20740676 | 0.76 | DHFR (0.48) | DHFRTP53TSHRSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194985-B1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2019-02-20 | — | — | EP | claimed |
| EP-2194985-B1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2019-02-20 | — | — | EP | disclosed |