Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 4/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.36 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1470518 | 1.00 | SLC6A1 (0.36) | SLC6A1GABRA5GABRB2SLC6A11SLC6A13 | |
| SCHEMBL27198371 | 1.00 | SLC6A1 (0.36) | SLC6A1GABRA5GABRB2SLC6A11SLC6A13 | |
| SCHEMBL20136819 | 1.00 | SLC6A1 (0.36) | SLC6A1GABRA5GABRB2SLC6A11SLC6A13 | |
| SCHEMBL27145812 | 0.91 | GABRA5 (0.36) | SLC6A1GABRA5GABRB2SLC6A11SLC6A13 | |
| SCHEMBL334462 | 0.85 | SLC6A1 (0.36) | SLC6A1GABRA5GABRB2SLC6A11SLC6A13 | |
| SCHEMBL20744258 | 0.85 | SLC6A1 (0.36) | SLC6A1GABRA5GABRB2SLC6A11SLC6A13 | |
| SCHEMBL18692612 | 0.85 | SLC6A1 (0.36) | SLC6A1GABRA5GABRB2SLC6A11SLC6A13 | |
| SCHEMBL3579211 | 0.85 | PARP1 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1033901 | 0.85 | PARP1 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3582591 | 0.85 | PARP1 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668882-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019034890-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2019-02-21 | — | — | WO | disclosed |