Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | EHMT2 | Q96KQ7 | 7/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31458840 | 1.00 | TP53 (0.55) | TP53POLBGAATSHREHMT2 | |
| SCHEMBL20746217 | 0.95 | EHMT2 (0.59) | TP53POLBGAATSHREHMT2 | |
| SCHEMBL25489690 | 0.86 | ACHE (0.68) | POLBGAATSHREHMT2ACHE | |
| SCHEMBL22654166 | 0.85 | EHMT2 (0.73) | EHMT2ACHE | |
| SCHEMBL30239190 | 0.85 | EHMT2 (0.73) | EHMT2ACHE | |
| SCHEMBL20755403 | 0.85 | EHMT2 (0.72) | EHMT2ACHE | |
| SCHEMBL31458727 | 0.84 | ACHE (0.69) | TP53EHMT2ACHEMAPT | |
| SCHEMBL20745564 | 0.84 | ACHE (0.69) | TP53EHMT2ACHEMAPT | |
| SCHEMBL20746263 | 0.82 | EHMT2 (0.61) | EHMT2ACHENPC1RAB9A | |
| SCHEMBL30239309 | 0.82 | EHMT2 (0.61) | EHMT2ACHENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668863-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |