Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 14/20 | 0.59 |
| ▸ | ACHE | P22303 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20745991 | 0.95 | TP53 (0.55) | EHMT2ACHETP53POLBGAA | |
| SCHEMBL31458840 | 0.95 | TP53 (0.55) | EHMT2ACHETP53POLBGAA | |
| SCHEMBL20745564 | 0.91 | ACHE (0.69) | EHMT2ACHETP53APPBCHE | |
| SCHEMBL31458727 | 0.91 | ACHE (0.69) | EHMT2ACHETP53APPBCHE | |
| SCHEMBL22654166 | 0.91 | EHMT2 (0.73) | EHMT2ACHEAPPBCHE | |
| SCHEMBL30239190 | 0.91 | EHMT2 (0.73) | EHMT2ACHEAPPBCHE | |
| SCHEMBL20755403 | 0.90 | EHMT2 (0.72) | EHMT2ACHEAPPBCHEENPP1 | |
| SCHEMBL20745971 | 0.88 | ACHE (0.74) | EHMT2ACHETP53APPBCHE | |
| SCHEMBL20746263 | 0.88 | EHMT2 (0.61) | EHMT2ACHEAPPBCHE | |
| SCHEMBL30239309 | 0.88 | EHMT2 (0.61) | EHMT2ACHEAPPBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668863-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |