Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460357 | 0.77 | L3MBTL1 (0.49) | ALDH1A1MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL17844326 | 0.77 | L3MBTL1 (0.49) | ALDH1A1MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL29809671 | 0.77 | L3MBTL1 (0.49) | ALDH1A1MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL4547926 | 0.77 | L3MBTL1 (0.49) | ALDH1A1MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL6080968 | 0.76 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AL3MBTL1CYP1A2 | |
| SCHEMBL4715545 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KMT2APKMLMNA | |
| SCHEMBL21202392 | 0.74 | L3MBTL1 (0.46) | ALDH1A1MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL5337121 | 0.74 | L3MBTL1 (0.47) | ALDH1A1MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL27536638 | 0.74 | L3MBTL1 (0.47) | ALDH1A1MEN1KMT2AL3MBTL1AKR1C3 | |
| SCHEMBL515194 | 0.72 | L3MBTL1 (0.45) | ALDH1A1MEN1KMT2AL3MBTL1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019036024-A1 | 2-(1,1 '-BIPHENYL)-1 H-BENZO[D]IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS APELIN AND APJ AGONISTS FOR TREATING CARDIOVASCULAR DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-21 | — | — | WO | disclosed |