Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 6/20 | 0.45 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.45 |
| ▸ | GUSB | P08236 | 2/20 | 0.44 |
| ▸ | EBP | Q15125 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19275195 | 1.00 | GNAI3 (0.45) | GNAI3GNAO1GNAI1GUSBEBP | |
| SCHEMBL19710786 | 0.86 | GNAI3 (0.45) | GNAI3GNAO1GNAI1GUSBEBP | |
| SCHEMBL38666415 | 0.86 | GNAI3 (0.45) | GNAI3GNAO1GNAI1GUSBEBP | |
| SCHEMBL27317078 | 0.82 | GNAI3 (0.41) | GNAI3GNAO1GNAI1GUSBEBP | |
| SCHEMBL21741326 | 0.80 | DRD2 (0.30) | SIGMAR1 | |
| SCHEMBL5903552 | 0.77 | S1PR1 (0.42) | GNAI3GNAO1GNAI1GUSBEBP | |
| SCHEMBL16508917 | 0.76 | NOS3 (0.40) | GNAI3GNAO1GNAI1GUSBEBP | |
| SCHEMBL25653853 | 0.76 | S1PR1 (0.44) | GNAI3GNAO1GNAI1GUSBEBP | |
| SCHEMBL24261257 | 0.76 | S1PR1 (0.49) | GNAI3GNAO1GNAI1GUSBEBP | |
| SCHEMBL17350998 | 0.76 | S1PR1 (0.49) | GNAI3GNAO1GNAI1GUSBEBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718641-B2 | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| US-10208081-B2 | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10208081-B2 | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | GPBAR1, NR1H4, SLC10A1 | GNAI3 280/4885GNAO1 270/4885GNAI1 254/4885 |
| US-11718641-B2 | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | GPBAR1, NR1H4, SLC10A1 | GNAI3 280/4885GNAO1 270/4885GNAI1 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.