Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 10/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14817010 | 0.87 | KDM4E (0.42) | HTR4RBP4NR1I2EGFRADRA2A | |
| SCHEMBL1405882 | 0.75 | KDM4E (0.42) | HTR4KDM4EELANEALDH1A1SMN1; SMN2 | |
| SCHEMBL27051631 | 0.74 | NR1I2 (0.38) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL20116565 | 0.74 | GRM4 (0.44) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL498685 | 0.71 | NLRP3 (0.46) | HTR4RBP4ELANEHPGD | |
| SCHEMBL3222301 | 0.71 | HTR4 (0.39) | HTR4KDM4EELANEALDH1A1SMN1; SMN2 | |
| SCHEMBL26373750 | 0.71 | NR1I2 (0.38) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL27051630 | 0.71 | RET (0.38) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL20117051 | 0.71 | SYK (0.36) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL8876380 | 0.69 | EGFR (0.40) | HTR4RBP4EGFRADRA2AELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233831-B1 | NOVEL FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES INC (US) | 2019-02-20 | — | — | EP | disclosed |