Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15819752 | 0.82 | EZH2 (0.47) | EZH2 | |
| SCHEMBL15820064 | 0.82 | EZH2 (0.49) | EZH2 | |
| SCHEMBL20749672 | 0.81 | SIGMAR1 (0.47) | — | |
| SCHEMBL20749697 | 0.81 | EZH2 (0.42) | EZH2 | |
| SCHEMBL15839088 | 0.72 | EZH2 (0.64) | EZH2 | |
| SCHEMBL19390938 | 0.72 | EZH2 (0.48) | EZH2 | |
| SCHEMBL16398000 | 0.72 | EZH2 (0.59) | EZH2 | |
| SCHEMBL15838999 | 0.72 | EZH2 (0.62) | EZH2 | |
| SCHEMBL16402409 | 0.72 | EZH2 (0.57) | EZH2 | |
| SCHEMBL19390945 | 0.72 | EZH2 (0.46) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935214-B1 | 1,4-PYRIDONE COMPOUNDS | EPIZYME INC (US) | 2019-02-20 | — | — | EP | disclosed |