Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16398094 | 0.85 | OPRM1 (0.50) | SIGMAR1HRH3HTR1ASLC6A4OPRM1 | |
| SCHEMBL16398375 | 0.85 | OPRM1 (0.49) | SIGMAR1HRH3HTR1ASLC6A4OPRM1 | |
| SCHEMBL20749761 | 0.81 | EZH2 (0.39) | — | |
| SCHEMBL16402619 | 0.76 | EZH2 (0.53) | — | |
| SCHEMBL15839169 | 0.76 | EZH2 (0.57) | — | |
| SCHEMBL19390905 | 0.76 | EZH2 (0.42) | OPRM1OPRD1OPRK1CCR4 | |
| SCHEMBL16402441 | 0.76 | EZH2 (0.51) | — | |
| SCHEMBL15839173 | 0.75 | EZH2 (0.56) | — | |
| SCHEMBL15839157 | 0.75 | EZH2 (0.56) | — | |
| SCHEMBL20749697 | 0.73 | EZH2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935214-B1 | 1,4-PYRIDONE COMPOUNDS | EPIZYME INC (US) | 2019-02-20 | — | — | EP | disclosed |