Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15786403 | 0.76 | MARK3 (0.31) | MARK3 | |
| SCHEMBL13961730 | 0.75 | MARK3 (0.30) | MARK3 | |
| SCHEMBL13340902 | 0.74 | MARK3 (0.30) | MARK3 | |
| SCHEMBL15783495 | 0.73 | TDP1 (0.31) | — | |
| SCHEMBL18237838 | 0.71 | USP19 (0.41) | MEN1KMT2AALDH1A1BRD4ADRA2A | |
| SCHEMBL8654708 | 0.69 | ALDH1A1 (0.40) | BACE1BACE2KMT2AMARK3ALDH1A1 | |
| SCHEMBL25891411 | 0.68 | ALDH1A1 (0.44) | BACE1BACE2MEN1KMT2AMARK3 | |
| SCHEMBL15790780 | 0.68 | HDAC6 (0.48) | HDAC6NPC1ALDH1A1POLBBRD4 | |
| SCHEMBL16601592 | 0.67 | KMT2A (0.38) | MEN1KMT2AALPLALDH1A1POLB | |
| SCHEMBL12904005 | 0.64 | HDAC6 (0.48) | HDAC6MEN1KMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |