Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13367651 | 0.84 | RXRA (0.43) | KMT2AMEN1MAPTMAPK1TDP1 | |
| SCHEMBL13340907 | 0.82 | KMT2A (0.36) | KMT2AMEN1ALDH1A1POLBPKM | |
| SCHEMBL16601589 | 0.80 | GABRG2 (0.42) | KMT2AMEN1MAPTALDH1A1POLB | |
| SCHEMBL16601602 | 0.79 | NR3C2 (0.40) | KMT2AMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL15786403 | 0.74 | MARK3 (0.31) | — | |
| SCHEMBL9971083 | 0.74 | MEN1 (0.34) | KMT2AMEN1ALPLPARK7 | |
| SCHEMBL16601596 | 0.73 | TSHR (0.55) | KMT2AMEN1ALDH1A1POLBCYP2C19 | |
| SCHEMBL13367642 | 0.72 | MAPT (0.39) | KMT2AMEN1MAPTALDH1A1POLB | |
| SCHEMBL16601598 | 0.72 | ALDH1A1 (0.40) | KMT2AMEN1MAPTALDH1A1POLB | |
| SCHEMBL13212459 | 0.72 | MAPK1 (0.42) | KMT2AMEN1MAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |