Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2075166 | 0.98 | HTR6 (0.44) | HTR6SIGMAR1HRH3HPGDKMT2A | |
| SCHEMBL943337 | 0.78 | HTR6 (0.64) | HTR6HRH3HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL451992 | 0.78 | HTR6 (0.64) | HTR6HRH3HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL1267270 | 0.78 | HTR6 (0.64) | HTR6HRH3HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL43171 | 0.78 | HTR6 (0.64) | HTR6HRH3HPGDKMT2ASMN1; SMN2 | |
| Iodomethane SCHEMBL27811080 | 0.77 | HTR6 (0.57) | HTR6HRH3HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL24375671 | 0.76 | SLC6A2 (0.47) | KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7897603 | 0.76 | SLC6A2 (0.47) | KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18531650 | 0.76 | SLC6A2 (0.47) | KMT2ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL6499302 | 0.76 | HTR6 (0.61) | HTR6HRH3HPGDKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902184-B2 | Piperazinyl pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-03-08 | — | — | US | disclosed |
| US-20070281921-A1 | Piperidinyl pyrimidine derivatives | HOFFMAN-LA ROCHE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281921-A1 | Piperidinyl pyrimidine derivatives | HRH2, P2RX5, P2RX3 | HTR6 151/4885SIGMAR1 222/4885HRH3 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.