Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | BID | P55957 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569982 | 0.85 | ALDH1A1 (0.73) | ALDH1A1KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL1154557 | 0.83 | KDM4E (0.71) | ALDH1A1KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL16793536 | 0.83 | KDM4E (0.71) | ALDH1A1KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL823501 | 0.81 | KDM4E (1.00) | ALDH1A1KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL10934231 | 0.81 | KDM4E (0.68) | ALDH1A1KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL3076269 | 0.81 | KDM4E (0.68) | ALDH1A1KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL29599792 | 0.81 | KDM4E (1.00) | ALDH1A1KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL22964425 | 0.79 | KDM4E (0.66) | ALDH1A1KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL2072485 | 0.78 | KDM4E (1.00) | ALDH1A1KDM4EHSD17B10HPGDDRD2 | |
| SCHEMBL2783529 | 0.77 | KDM4E (0.62) | ALDH1A1KDM4EHSD17B10HPGDDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |