Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20757090 | 0.82 | HRH4 (0.47) | HRH4ACACBMAPK1 | |
| SCHEMBL25065331 | 0.76 | HRH3 (0.40) | HRH3 | |
| SCHEMBL20756622 | 0.75 | CHRNB2 (0.39) | HRH4 | |
| SCHEMBL20756582 | 0.75 | LDHA (0.42) | HRH4LDHAACACB | |
| SCHEMBL24844050 | 0.72 | DPP4 (0.41) | HRH3 | |
| SCHEMBL24746028 | 0.71 | CHRNB2 (0.41) | HRH3 | |
| SCHEMBL23108878 | 0.70 | HRH3 (0.40) | HRH3MAPK1 | |
| SCHEMBL23108681 | 0.70 | HRH3 (0.40) | HRH3MAPK1 | |
| SCHEMBL23132890 | 0.70 | HRH3 (0.40) | HRH3MAPK1 | |
| SCHEMBL23132893 | 0.70 | HRH3 (0.40) | HRH3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |