Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 11/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2875033 | 0.80 | NFE2L2 (0.65) | NFE2L2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL9967778 | 0.80 | NFE2L2 (0.65) | NFE2L2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL31317689 | 0.73 | NFE2L2 (1.00) | NFE2L2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL700537 | 0.73 | NFE2L2 (1.00) | NFE2L2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL700536 | 0.73 | NFE2L2 (1.00) | NFE2L2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL27632020 | 0.70 | NFE2L2 (0.74) | NFE2L2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL257117 | 0.70 | NFE2L2 (0.74) | NFE2L2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL14634506 | 0.70 | NFE2L2 (0.74) | NFE2L2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL8175617 | 0.70 | NFE2L2 (0.74) | NFE2L2CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL11326237 | 0.70 | NFE2L2 (0.50) | NFE2L2RELAPTGS1PTGS2NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018005445-A9 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DIABETES | THE BROAD INSTITUTE, INC. (US) | 2019-02-21 | — | — | WO | disclosed |