Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257275 | 0.88 | PNMT (0.51) | PNMTRXFP1CES2ALDH1A1AURKB | |
| SCHEMBL20764643 | 0.86 | RXFP1 (0.43) | RXFP1CES2ALDH1A1POLBAURKB | |
| SCHEMBL6237655 | 0.85 | CTSS (0.45) | CES2ALDH1A1NQO2CTSSCTSK | |
| SCHEMBL3137524 | 0.84 | NQO2 (0.43) | NQO2CTSSCTSK | |
| SCHEMBL16079975 | 0.84 | POLB (0.45) | ALDH1A1POLBNQO2NPSR1CTSS | |
| SCHEMBL17735443 | 0.84 | POLB (0.45) | ALDH1A1POLBNQO2NPSR1CTSS | |
| SCHEMBL16031480 | 0.84 | NQO2 (0.51) | NQO2CTSSCTSK | |
| SCHEMBL2204205 | 0.84 | NQO2 (0.51) | NQO2CTSSCTSK | |
| SCHEMBL26577144 | 0.84 | PNMT (0.50) | PNMTRXFP1CES2ALDH1A1POLB | |
| SCHEMBL12184924 | 0.84 | PNMT (0.55) | PNMTCES2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672953-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | Acesion Pharma ApS (DK) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019038315-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | ACESION PHARMA APS (DK) | 2019-02-28 | — | — | WO | disclosed |