Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | ADAM10 | O14672 | 12/20 | 0.38 |
| ▸ | MMP2 | P08253 | 9/20 | 0.38 |
| ▸ | MMP3 | P08254 | 5/20 | 0.38 |
| ▸ | MMP9 | P14780 | 5/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22653958 | 0.85 | GPR119 (0.33) | GPR119 | |
| SCHEMBL1747687 | 0.83 | GPR119 (0.45) | GPR119ADAM10MMP2MMP3MMP9 | |
| SCHEMBL8188382 | 0.77 | — | — | |
| SCHEMBL1747773 | 0.77 | GPR119 (0.45) | GPR119ADAM10MMP2MMP3MMP9 | |
| SCHEMBL8262694 | 0.77 | GPR119 (0.47) | GPR119ADAM10MMP2MMP3MMP9 | |
| SCHEMBL8276655 | 0.76 | GPR119 (0.44) | GPR119ADAM10MMP2MMP3MMP9 | |
| SCHEMBL21078147 | 0.75 | ADAM10 (0.40) | GPR119ADAM10MMP2MMP3MMP9 | |
| SCHEMBL17888257 | 0.75 | GPR119 (0.42) | GPR119ADAM10MMP2MMP3MMP9 | |
| SCHEMBL20764836 | 0.74 | GPR119 (0.39) | GPR119ADAM10MMP2MMP3MMP9 | |
| SCHEMBL17886595 | 0.73 | GPR119 (0.43) | GPR119ADAM10MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038362-A1 | ANTIBACTERIAL PYRROLOIMIDAZOLONES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-02-28 | — | — | WO | claimed |
| WO-2019038362-A1 | ANTIBACTERIAL PYRROLOIMIDAZOLONES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-02-28 | — | — | WO | disclosed |