Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 13/20 | 0.40 |
| ▸ | MMP2 | P08253 | 10/20 | 0.40 |
| ▸ | MMP3 | P08254 | 5/20 | 0.40 |
| ▸ | MMP9 | P14780 | 5/20 | 0.40 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21078126 | 0.89 | JAK2 (0.35) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL21078142 | 0.84 | PRSS1 (0.35) | ADAM10MMP2MMP9JAK2JAK1 | |
| SCHEMBL17888257 | 0.84 | GPR119 (0.42) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL17886595 | 0.82 | GPR119 (0.43) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL21078128 | 0.77 | NAMPT (0.50) | — | |
| SCHEMBL20764784 | 0.75 | GPR119 (0.41) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL21077917 | 0.73 | NAMPT (0.48) | — | |
| SCHEMBL1747687 | 0.73 | GPR119 (0.45) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL17888249 | 0.72 | JAK2 (0.36) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL21078133 | 0.70 | L3MBTL1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |