Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 3/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342553 | 0.79 | NPC1 (0.34) | CNR2NPC1RAB9ACTSAPOLB | |
| SCHEMBL2078459 | 0.69 | — | — | |
| SCHEMBL2040743 | 0.66 | CTSA (0.40) | CNR2CTSANR3C1HSPA5MAPKAPK2 | |
| SCHEMBL21814162 | 0.66 | NPC1 (0.48) | NPC1RAB9ACTSAHSPA5MAPKAPK2 | |
| SCHEMBL4480948 | 0.66 | NPC1 (0.48) | NPC1RAB9ACTSAHSPA5MAPKAPK2 | |
| SCHEMBL7466599 | 0.65 | ABCB1 (0.50) | CNR2 | |
| SCHEMBL2078475 | 0.65 | CYP26A1 (0.37) | RAB9A | |
| SCHEMBL7269208 | 0.64 | CA2 (0.36) | CTSA | |
| SCHEMBL7275363 | 0.64 | CA2 (0.36) | CTSA | |
| SCHEMBL1860034 | 0.64 | CA12 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163909-B2 | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2012-04-24 | — | — | US | disclosed |