Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20765465 | 1.00 | IDH1 (0.37) | IDH1KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL20765519 | 0.91 | MEN1 (0.38) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL20765521 | 0.91 | MEN1 (0.38) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL20765470 | 0.85 | BCHE (0.39) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL20774925 | 0.84 | ALDH1A1 (0.52) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL20765619 | 0.83 | ALDH1A1 (0.40) | MEN1ALDH1A1KMT2A | |
| SCHEMBL20765618 | 0.83 | ALDH1A1 (0.40) | MEN1ALDH1A1KMT2A | |
| SCHEMBL20765600 | 0.81 | CHEK2 (0.42) | KDM4EALDH1A1PKM | |
| SCHEMBL20766547 | 0.79 | PKM (0.42) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL20766545 | 0.79 | PKM (0.42) | KDM4EMEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038683-A1 | COMPOUNDS TARGETING TANDEM BRCT DOMAINS OF BRCA1, COMPOSITIONS AND METHODS THEREOF | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (IN) | 2019-02-28 | — | — | WO | claimed |