Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20766547 | 1.00 | PKM (0.42) | PKMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765548 | 0.85 | ALDH1A1 (0.40) | PKMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765545 | 0.85 | ALDH1A1 (0.40) | PKMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765519 | 0.82 | MEN1 (0.38) | PKMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765521 | 0.82 | MEN1 (0.38) | PKMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765470 | 0.81 | BCHE (0.39) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL20765606 | 0.81 | GHSR (0.52) | ALDH1A1KDM4E | |
| SCHEMBL20765603 | 0.81 | GHSR (0.52) | ALDH1A1KDM4E | |
| SCHEMBL20765463 | 0.80 | GRIN1 (0.41) | ALDH1A1HTTMAPK1NPSR1 | |
| SCHEMBL20765520 | 0.78 | HRH3 (0.43) | PKMALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038683-A1 | COMPOUNDS TARGETING TANDEM BRCT DOMAINS OF BRCA1, COMPOSITIONS AND METHODS THEREOF | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (IN) | 2019-02-28 | — | — | WO | claimed |