Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20782579 | 0.94 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20765580 | 0.90 | KDM4E (0.50) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20765528 | 0.89 | ALDH1A1 (0.50) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20765510 | 0.87 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20765555 | 0.87 | ALDH1A1 (0.66) | ALDH1A1KDM4EMEN1KMT2AHTT | |
| SCHEMBL20765631 | 0.86 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20765593 | 0.86 | KDM4E (0.48) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20765497 | 0.86 | MGLL (0.58) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20765674 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20765710 | 0.85 | HPGD (0.48) | ALDH1A1KDM4ELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038683-A1 | COMPOUNDS TARGETING TANDEM BRCT DOMAINS OF BRCA1, COMPOSITIONS AND METHODS THEREOF | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (IN) | 2019-02-28 | — | — | WO | claimed |
| WO-2019038683-A1 | COMPOUNDS TARGETING TANDEM BRCT DOMAINS OF BRCA1, COMPOSITIONS AND METHODS THEREOF | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (IN) | 2019-02-28 | — | — | WO | disclosed |