Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20766870 | 0.80 | MAPK1 (0.54) | TAS1R3TAS1R1HDAC8ALDH1A1RAB9A | |
| SCHEMBL30566676 | 0.80 | MAPK1 (0.54) | TAS1R3TAS1R1HDAC8ALDH1A1RAB9A | |
| SCHEMBL20766944 | 0.77 | HDAC1 (0.50) | HDAC1HDAC3HDAC2NCOR2NCOR1 | |
| SCHEMBL30739959 | 0.76 | TAS1R3 (0.58) | HDAC1TAS1R3TAS1R1TAS1R2RORC | |
| SCHEMBL18146367 | 0.76 | TAS1R3 (0.58) | HDAC1TAS1R3TAS1R1TAS1R2RORC | |
| SCHEMBL18147101 | 0.76 | MEN1 (0.52) | HDAC1TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL20371016 | 0.76 | CYP1A2 (0.64) | RORCNPC1RAB9A | |
| SCHEMBL21022405 | 0.73 | HDAC1 (0.54) | HDAC1HDAC3HDAC2NCOR2NCOR1 | |
| SCHEMBL15331049 | 0.73 | HPGD (0.55) | KDM4ENPC1ALDH1A1RAB9ATP53 | |
| SCHEMBL18147944 | 0.72 | MAPT (0.50) | HDAC1TAS1R3TAS1R1TAS1R2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11229638-B2 | Therapeutic heterocyclic compounds | GILEAD SCIENCES, INC. (US) | 2022-01-25 | — | — | US | disclosed |
| US-11040033-B2 | Therapeutic heterocyclic compounds | GILEAD SCIENCES, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-20200316035-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. | 2020-10-08 | — | — | US | disclosed |
| EP-3672970-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | Gilead Sciences, Inc. (US) | 2020-07-01 | — | — | EP | disclosed |
| CN-111051305-A | Therapeutic heterocyclic compounds | 吉利德科学公司 | 2020-04-21 | — | — | CN | disclosed |
| US-20190192504-A1 | Therapeutic heterocyclic compounds | GILEAD SCIENCES, INC. | 2019-06-27 | — | — | US | disclosed |
| WO-2019040102-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2019-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11229638-B2 | Therapeutic heterocyclic compounds | SDHA, CYP11B2, ABCB1 | HDAC1 207/4885HDAC3 198/4885HDAC2 428/4885 |
| US-20190192504-A1 | Therapeutic heterocyclic compounds | SDHA, CYP11B2, ABCB1 | HDAC1 207/4885HDAC3 198/4885HDAC2 428/4885 |
| US-11040033-B2 | Therapeutic heterocyclic compounds | SDHA, CYP11B2, ABCB1 | HDAC1 207/4885HDAC3 198/4885HDAC2 428/4885 |
| US-20200316035-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | SDHA, CYP11B2, ABCB1 | HDAC1 207/4885HDAC3 198/4885HDAC2 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.