Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.83 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3900072 | 0.77 | KDM4E (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL22718492 | 0.77 | KDM4E (0.61) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL20767014 | 0.76 | MEN1 (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL2284269 | 0.74 | ALDH1A1 (0.57) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL11534549 | 0.74 | KDM4E (1.00) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL16796325 | 0.73 | KDM4E (0.65) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL23508915 | 0.72 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL20610586 | 0.71 | ALDH1A1 (0.55) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL13325866 | 0.70 | ALDH1A1 (0.77) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL948580 | 0.70 | KDM4E (0.77) | ALDH1A1KDM4EMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672970-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | Gilead Sciences, Inc. (US) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019040102-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2019-02-28 | — | — | WO | disclosed |