Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13325871 | 0.81 | KDM4E (0.61) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL11534549 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL948580 | 0.78 | KDM4E (0.77) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL13325866 | 0.74 | ALDH1A1 (0.77) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL6840370 | 0.74 | ALDH1A1 (0.60) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL22406344 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL20766941 | 0.73 | ALDH1A1 (0.83) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL7120114 | 0.73 | KDM4E (0.59) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL13325867 | 0.73 | MEN1 (1.00) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL20610586 | 0.72 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTLIMK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080101-A1 | MONOCYCLIC PYRIMIDINE/PYRIDINE COMPOUNDS AS INHIBITORS OF P97 COMPLEX | Cleave Biosciences, Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015089218-A1 | MONOCYCLIC PYRIMIDINE/PYRIDINE COMPOUNDS AS INHIBITORS OF P97 COMPLEX | WUSTROW DAVID (US) | 2015-06-18 | — | — | WO | disclosed |