Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.77 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.77 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.77 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 6/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11534549 | 0.87 | KDM4E (1.00) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL13325866 | 0.82 | ALDH1A1 (0.77) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL13325867 | 0.81 | MEN1 (1.00) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL31215225 | 0.80 | MEN1 (0.69) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL16796325 | 0.78 | KDM4E (0.65) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL13325865 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL13325871 | 0.75 | KDM4E (0.61) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL10095082 | 0.75 | KDM4E (0.66) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL13325870 | 0.75 | KDM4E (0.65) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL4917654 | 0.72 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTLIMK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |
| US-20110009389-A1 | IMIDAZOLE DERIVATIVE, THEIR PRODUCTION AND USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-01-13 | — | — | US | disclosed |
| US-20070004736-A1 | Imidazole derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-04 | — | — | US | disclosed |
| EP-1564213-A1 | IMIDAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE | Takeda Pharmaceutical Company Limited (JP) | 2005-08-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004736-A1 | Imidazole derivative, process for producing the same, and use | HRH4, F2, HRH2 | KDM4E 1356/4885ALDH1A1 2246/4885MAPT 4771/4885 |
| US-20110009389-A1 | IMIDAZOLE DERIVATIVE, THEIR PRODUCTION AND USE | F2, H1-3, CYC1 | KDM4E 1558/4885ALDH1A1 2316/4885MAPT 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.