Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 4/20 | 0.51 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.50 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20767219 | 0.84 | LMNA (0.63) | ALDH1A1TP53POLBTDP1LMNA | |
| SCHEMBL22874674 | 0.81 | MAOB (0.71) | ALDH1A1TP53SMN1; SMN2KDM4ELMNA | |
| SCHEMBL20767235 | 0.81 | MEN1 (0.48) | ALDH1A1SMN1; SMN2KDM4ELMNAGAA | |
| SCHEMBL20766940 | 0.79 | MAPK1 (0.55) | ALDH1A1TP53POLBTDP1KDM4E | |
| SCHEMBL21165344 | 0.78 | MPO (0.57) | POLBTDP1MEN1KMT2AMAOB | |
| SCHEMBL30753812 | 0.77 | MPO (0.55) | MAOBSCN8AMAOA | |
| SCHEMBL2720282 | 0.77 | MPO (0.55) | MAOBSCN8AMAOA | |
| SCHEMBL28207660 | 0.76 | CHRM2 (0.62) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL20804366 | 0.76 | MPO (0.54) | MAOBSCN8AMAOA | |
| SCHEMBL11482232 | 0.76 | MAOB (0.56) | SMN1; SMN2KDM4EMAOBSCN8AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040105-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |
| WO-2019040105-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |