Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 16/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247322 | 0.80 | AKR1B1 (0.57) | AKR1B1PTGDR2 | |
| SCHEMBL9321434 | 0.80 | AKR1B1 (0.67) | AKR1B1PTGDR2 | |
| SCHEMBL9322563 | 0.79 | AKR1B1 (0.66) | AKR1B1 | |
| SCHEMBL9218891 | 0.78 | AKR1B1 (0.66) | AKR1B1CYP1A2CYP2C9PTGDR2 | |
| SCHEMBL9322351 | 0.77 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL9323846 | 0.77 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL20769651 | 0.76 | ALDH1A1 (0.60) | CYP2C9NPSR1CCR2SLC22A12 | |
| SCHEMBL8038414 | 0.75 | AKR1B1 (0.53) | AKR1B1 | |
| SCHEMBL9323969 | 0.74 | AKR1B1 (0.51) | AKR1B1PTGDR2 | |
| SCHEMBL5317956 | 0.73 | AKR1B1 (0.56) | AKR1B1CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |