Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12984735 | 0.88 | KMO (0.52) | AKR1B1MAPK8MAPK9MAPK10KDM4C | |
| SCHEMBL3247322 | 0.83 | AKR1B1 (0.57) | AKR1B1MAPK8KMOPTGDR2 | |
| SCHEMBL16881243 | 0.80 | MAPK8 (0.49) | MAPK8MAPK9MAPK10KDM4C | |
| SCHEMBL13106420 | 0.80 | MAPK8 (0.56) | MAPK8MAPK9MAPK10KDM4C | |
| SCHEMBL15898846 | 0.80 | GABRA1 (0.48) | MAPK8MAPK9MAPK10KDM4C | |
| SCHEMBL8415002 | 0.78 | MAPT (0.54) | AKR1B1PTGDR2 | |
| Fumaric Acid SCHEMBL8138712 | 0.78 | MAPK8 (0.53) | MAPK8MAPK9MAPK10KDM4C | |
| SCHEMBL10253820 | 0.77 | KDM4C (0.52) | MAPK8MAPK9MAPK10KDM4CKMO | |
| Fumaric Acid SCHEMBL8138713 | 0.76 | MAPK8 (0.40) | MAPK8MAPK9MAPK10KDM4CKMO | |
| Fumaric Acid SCHEMBL8138709 | 0.76 | MAPK8 (0.40) | MAPK8MAPK9MAPK10KDM4CKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330997-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1994-07-19 | — | — | US | disclosed |
| US-5236945-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0325375-B1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1989006651-A1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1989-07-27 | — | — | WO | disclosed |
| EP-0325375-A1 | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1989-07-26 | — | — | EP | disclosed |
| US-4008070-A | ALKYL 5-HALO-1H-INDAZOLE-3-ACETATE | NISSAN CHEMICAL INDUSTRIES CO., LTD. (JA) | 1977-02-15 | — | — | US | disclosed |