Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 11/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11753420 | 0.83 | AKR1B1 (0.54) | AKR1B1MAPTPTGDR2 | |
| SCHEMBL9323969 | 0.83 | AKR1B1 (0.51) | AKR1B1PTGDR2KMOMAPK8 | |
| SCHEMBL20769718 | 0.80 | AKR1B1 (0.62) | AKR1B1PTGDR2 | |
| SCHEMBL10533803 | 0.80 | MAPT (0.71) | AKR1B1MAPT | |
| SCHEMBL9321434 | 0.76 | AKR1B1 (0.67) | AKR1B1PTGDR2 | |
| SCHEMBL9322563 | 0.75 | AKR1B1 (0.66) | AKR1B1 | |
| SCHEMBL12984735 | 0.74 | KMO (0.52) | AKR1B1PTGDR2KMOMAPK8 | |
| SCHEMBL24182151 | 0.74 | ADORA2A (0.62) | MAPTKMOMAPK8 | |
| SCHEMBL9322351 | 0.74 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL9323846 | 0.74 | AKR1B1 (1.00) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4008070-A | ALKYL 5-HALO-1H-INDAZOLE-3-ACETATE | NISSAN CHEMICAL INDUSTRIES CO., LTD. (JA) | 1977-02-15 | — | — | US | claimed |
| US-20100234226-A1 | HERBICIDE COMBINATION COMPRISING DIMETHOXYTRIAZINYL-SUBSTITUTED DIFLUOROMETHANESULFONYLANILIDES | BAYER CROPSCIENCE AG (DE) | 2010-09-16 | — | — | US | disclosed |
| WO-2010017926-A2 | HERBICIDAL COMBINATION COMPRISING DIMETHOXY-TRIAZINYL-SUBSTITUTED DIFLUOROMETHANE SULFONYLANILIDES | BAYER CROPSCIENCE AG (DE) | 2010-02-18 | — | — | WO | disclosed |
| US-5330997-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1994-07-19 | — | — | US | disclosed |
| US-5236945-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0325375-B1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1989006651-A1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1989-07-27 | — | — | WO | disclosed |
| EP-0325375-A1 | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1989-07-26 | — | — | EP | disclosed |
| US-4008070-A | ALKYL 5-HALO-1H-INDAZOLE-3-ACETATE | NISSAN CHEMICAL INDUSTRIES CO., LTD. (JA) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234226-A1 | HERBICIDE COMBINATION COMPRISING DIMETHOXYTRIAZINYL-SUBSTITUTED DIFLUOROMETHANESULFONYLANILIDES | DDT, CBR3, AS3MT | AKR1B1 497/4885MAPT 4433/4885PTGDR2 2312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.