Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 3/20 | 0.53 |
| ▸ | SNCA | P37840 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940378 | 0.87 | PTGDR2 (0.61) | PTGDR2ALDH1A1LMNA | |
| SCHEMBL20791839 | 0.85 | APP (0.53) | PTGDR2APPSNCAHDAC3CNR1 | |
| SCHEMBL9261699 | 0.83 | CDC25A (0.47) | PTGDR2HDAC3 | |
| SCHEMBL20769747 | 0.80 | ALDH1A1 (0.53) | PTGDR2ALDH1A1LMNAP2RX7 | |
| SCHEMBL9263809 | 0.80 | KDM4E (0.42) | PTGDR2ALDH1A1LMNAHDAC3 | |
| SCHEMBL2051630 | 0.79 | ALDH1A1 (0.80) | ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL20791838 | 0.76 | L3MBTL1 (0.56) | PTGDR2APPSNCACNR1CNR2 | |
| SCHEMBL14857618 | 0.76 | APP (0.55) | PTGDR2APPSNCAHDAC3CNR1 | |
| SCHEMBL13204251 | 0.75 | HDAC3 (0.55) | PTGDR2HDAC3CNR1CNR2 | |
| SCHEMBL12252047 | 0.75 | APP (0.65) | ALDH1A1LMNAAPPSNCACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |