Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.53 |
| ▸ | SNCA | P37840 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769724 | 0.85 | PTGDR2 (0.55) | APPSNCAL3MBTL1CNR1CNR2 | |
| SCHEMBL20791838 | 0.82 | L3MBTL1 (0.56) | APPSNCAL3MBTL1CNR1CNR2 | |
| SCHEMBL14857618 | 0.79 | APP (0.55) | APPSNCAL3MBTL1CNR1CNR2 | |
| SCHEMBL12252047 | 0.78 | APP (0.65) | APPSNCAL3MBTL1CNR1CNR2 | |
| SCHEMBL22252332 | 0.78 | CNR2 (0.53) | CNR1CNR2HDAC3PDE4ACFTR | |
| SCHEMBL12706043 | 0.76 | CHRNB2 (0.68) | L3MBTL1CYP19A1MEN1KMT2ACHRNB2 | |
| SCHEMBL12729841 | 0.76 | CNR2 (0.52) | APPSNCAL3MBTL1CNR1CNR2 | |
| SCHEMBL13168783 | 0.74 | CCNT1 (0.47) | PDE4ACFTRPDE4BPDE4CPDE4D | |
| SCHEMBL13168767 | 0.74 | KDM4E (0.45) | L3MBTL1CNR1CNR2HDAC3CFTR | |
| SCHEMBL88822 | 0.73 | GSK3B (0.54) | CNR1CNR2HDAC3CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |