Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nafenopin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.58 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.58 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nafenopin SCHEMBL184232 | 0.79 | MAPK1 (1.00) | MAPK1MAPK14BLMLMNAKDM4E | |
| Atropine SCHEMBL28098523 | 0.77 | CHRM1 (0.95) | CHRM2CHRM5CHRM1CHRM3HTR2C | |
| Atropine SCHEMBL2812 | 0.77 | CHRM1 (1.00) | CHRM2CHRM5CHRM1CHRM3HTR2C | |
| Atropine SCHEMBL41317 | 0.77 | CHRM1 (1.00) | CHRM2CHRM5CHRM1CHRM3HTR2C | |
| Atropine SCHEMBL14946873 | 0.77 | CHRM1 (1.00) | CHRM2CHRM5CHRM1CHRM3HTR2C | |
| Atropine SCHEMBL7941966 | 0.77 | CHRM1 (1.00) | CHRM2CHRM5CHRM1CHRM3HTR2C | |
| Atropine SCHEMBL2728129 | 0.77 | CHRM1 (1.00) | CHRM2CHRM5CHRM1CHRM3HTR2C | |
| Atropine SCHEMBL25020 | 0.77 | CHRM1 (1.00) | CHRM2CHRM5CHRM1CHRM3HTR2C | |
| Atropine SCHEMBL8854381 | 0.77 | CHRM1 (1.00) | CHRM2CHRM5CHRM1CHRM3HTR2C | |
| Atropine SCHEMBL249586 | 0.77 | CHRM1 (1.00) | CHRM2CHRM5CHRM1CHRM3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046303-A1 | A METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-07 | — | — | WO | disclosed |