SCHEMBL20771908

SCHEMBL20771908

CCOC(=O)c1nc(NC(CC)c2cccnc2)nc2ccsc12

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 18/20 0.71
ADORA2A P29274 14/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20784690 0.91 ADORA2B (0.74) ADORA2BADORA2A
SCHEMBL20784691 0.91 ADORA2B (0.74) ADORA2BADORA2A
SCHEMBL20784997 0.87 ADORA2B (0.89) ADORA2BADORA2A
SCHEMBL20771892 0.84 ADORA2B (0.54) ADORA2BADORA2A
SCHEMBL20784697 0.83 ADORA2B (1.00) ADORA2BADORA2A
SCHEMBL24261601 0.82 ADORA2B (1.00) ADORA2BADORA2A
SCHEMBL20784321 0.82 ADORA2B (1.00) ADORA2BADORA2A
SCHEMBL20784311 0.81 ADORA2B (0.78) ADORA2BADORA2A
SCHEMBL3707401 0.81 ADORA2B (0.78) ADORA2BADORA2A
SCHEMBL20784319 0.78 ADORA2B (0.80) ADORA2BADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11254686-B1 Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor CORVUS PHARMACEUTICALS, INC. (US) 2022-02-22 US disclosed
EP-3675856-A1 COMPOUNDS AND METHODS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR Corvus Pharmaceuticals, Inc. (US) 2020-07-08 EP disclosed
WO-2019046784-A1 COMPOUNDS AND METHODS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR CORVUS PHARMACEUTICALS, INC. (US) 2019-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11254686-B1 Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor ADORA2A, ADORA2B, ADORA3 ADORA2B 2/4885ADORA2A 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.