Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 16/20 | 1.00 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20777159 | 1.00 | TPH1 (1.00) | TPH1S1PR1NR1H4NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL22150732 | 0.99 | TPH1 (1.00) | TPH1S1PR1NR1H4NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL22150736 | 0.99 | TPH1 (1.00) | TPH1S1PR1NR1H4NPC1RAB9A | |
| SCHEMBL29810156 | 0.91 | TPH1 (0.82) | TPH1S1PR1NR1H4MAPTNPSR1 | |
| Hydrochloric Acid SCHEMBL29810149 | 0.90 | TPH1 (0.83) | TPH1S1PR1NR1H4MAPTNPSR1 | |
| SCHEMBL29810055 | 0.89 | TPH1 (1.00) | TPH1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL29810052 | 0.89 | TPH1 (0.80) | TPH1S1PR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29810064 | 0.88 | TPH1 (0.79) | TPH1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL29810079 | 0.88 | TPH1 (0.78) | TPH1NPC1RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29810180 | 0.88 | TPH1 (0.80) | TPH1S1PR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019039905-A1 | NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | 광주과학기술원 | 2019-02-28 | — | — | WO | disclosed |